HomocysteineFormula
90 tablets

Scientific evidence indicates healthy homocysteine levels are important for heart health.* Homocysteine levels are raised by: tobacco abuse, high cholesterol, coffee consumption, alcohol, high calorie diets, sedentary lifestyles, renal insufficiency, hypothyroidism, and theophylline. Moreover, low levels of B vitamins (folic acid, B6, and B12) also contribute to elevated homocysteine.

Homocysteine is produced from the amino acid methionine and remethylated to methionine, which requires vitamin B12 and folic acid. Homocysteine can also be reduced to cysteine through what is known as the transsulfuration pathway, which requires adequate levels of vitamin B6.

The HomocysteineFormula is a nutritional supplement that combines potent amounts of vitamins B6, B12, and folic acid and is designed for people who have high homocysteine levels. Because of significant variations in response among people taking this formula, it is best to monitor blood levels of homocysteine. Some people may benefit from additional supplementation with n-acetyl-cysteine (NAC) in order to achieve an optimal homocysteine level.*

Supplement Facts

Serving Size 1 tablet

Amount Per Serving
Vitamin B6 (as pyridoxine HCI)...........................25 mg 1250%
Folate (as folic acid)....................................3 mg 750% 
Vitamin B12 (as cyanocobalamin)...........................1 mg 16667%
Other ingredients: microcrystalline cellulose, croscarmellose 
sodium, stearic acid, magnesium stearate, pharmaceutical glaze.
  

This product contains NO milk, egg, fish, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast, or gluten. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. Although manufacturing equipment is thoroughly cleansed after all production runs, this product is manufactured in a facility that utilizes milk, egg, fish, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast, and gluten.

Directions: Take one (1) tablet daily with food, or as directed by your physician.

N.B. This product is available only with your physician's recommendation.

References

Bazzano LA, He J, Muntner P,et al. Relationship between cigarette smoking and novel risk factors for cardiovascular disease in the United States. Ann Intern Med. 2003 Jun 3;138(11):891-7.

De Bree A, Verschuren WM, Kromhout D, et al. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev. 2002 Dec;54(4):599-618.

Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study. J Clin Invest. 1996 Nov 1;98(9):2174-83.

Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005 Oct;82(4):806-12.

Arnadottir M, Hultberg B, Nilsson-Ehle P, et al. The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest. 1996 Feb;56(1):41-6.

Bostom AG, Shemin D, Lapane KL, et al. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int. 1996 Jan;49(1):147-52.

Nedrebø BG, Ericsson UB, Nygård O, et al. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism. 1998 Jan;47(1):89-93.

Ubbink JB, van der Merwe A, Delport R, et al. The effect of a subnormal vitamin B-6 status on homocysteine metabolism. J Clin Invest. 1996 Jul 1;98(1):177-84.

Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997 Jun 11;277(22):1775-81.

Rimm EB, Willett WC, Hu FB, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998 Feb 4;279(5):359-64.

El-Khairy L, Vollset SE, Refsum H, et al. Predictors of change in plasma total cysteine: longitudinal findings from the Hordaland homocysteine study. Clin Chem. 2003 Jan;49(1):113-20.

House JD, Jacobs RL, Stead LM, et al. Regulation of homocysteine metabolism. Adv Enzyme Regul. 1999;39:69-91.

Brattström L, Lindgren A, Israelsson B, et al. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med. 1994 Dec;236(6):633-41.

Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr. 1992
Jan;55(1):131-8.

Flicker L, Vasikaran SD, Thomas J, et al. Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia. Stroke. 2006 Feb;37(2):547-9. Epub 2005 Dec 22.

Raijmakers MT, Schilders GW, Roes EM, et al. N-Acetylcysteine improves the disturbed thiol redox balance after methionine loading. Clin Sci (Lond). 2003 Aug;105(2):173-80.

Roes EM, Raijmakers MT, Peters WH, et al. Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women. Clin Chem Lab Med. 2002 May;40(5):496-8.

Wiklund O, Fager G, Andersson A, et al. N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. Atherosclerosis. 1996 Jan 5;119(1):99-106.

Hultberg B, Andersson A, Masson P, et al. Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine. Scand J Clin Lab Invest. 1994 Oct;54(6):417-22.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.