Dialysist®
90 enteric coated capsules

Patients with Chronic Kidney Disease (CKD) represent a unique population with regard to nutritional requirements and appropriate supplementation. Dialysist® is a daily multivitamin and mineral formula designed to meet the nutritional needs for a specific state of kidney function. *

Dialysist® provides potent amounts of vitamin B6, vitamin B12 and folic acid to assist both of the body’s methylation pathways in maintaining healthy homocysteine levels, which is important for heart health. * N-acetyl-cysteine (NAC) is also included to help maintain healthy homocysteine levels and support healthy endothelial function. *

Supplement Facts

Serving Size 1 enteric coated capsule

Amount Per Serving
Vitamin C (as ascorbic acid)..........................................120 mg 200%
Vitamin D3 (as cholecalciferol).......................................400 IU 100%
Vitamin E (as d-alpha tocopheryl acetate and mixed tocopherols ........30 IU 100%
Vitamin B-1 (as Thiamine Mononitrate).........................3 mg 200%
Vitamin B-2 (as Riboflavin)...............................................3.4 mg 200%
Vitamin B-3 (as Niacinamide)...................................20 mg 100%
Vitamin B6 (as pyridoxine hydrochloride)...............................25 mg 1250%
Folic acid..............................................................5 mg 1250%
Vitamin B12 (as cyanocobalamin).........................................2 mg 33333%
Biotin...............................................................300 mcg 100%
Pantothenic acid (as d-calcium pantothenate).......................... 20 mg 200%
Zinc (as amino acid chelate)...........................................15 mg 100%
Selenium (as selenium amino acid chelate)......................................35 mcg 50%
Chromium (as chromium amino acid chelate)......................................60 mcg 50%
N-acetyl-L-cysteine (NAC)..............................................500 mg
Other ingredients: gelatin, magnesium stearate, silicon dioxide, methacrylic triacetin, FCC; vanilla flavor.

This product contains NO milk, egg, fish, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast, or gluten. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Although manufacturing equipment is thoroughly cleansed after all production runs, this product is manufactured in a facility that utilizes milk, egg, fish, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast, and gluten.

Directions: Take one (1) tablet daily with food, or as directed by your physician.

N.B. This product is available only with your physician’s recommendation.

References

Sahin G, Yalcin AU, Akcar N. Effect of N-Acetylcysteine on Endothelial Dysfunction in Dialysis Patients. Blood Purif. 2007 Jul 20;25(4):309-315.
Scholze A, Rinder C, Beige J, et al. Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure. Circulation. 2004 Jan 27;109(3):369-74.

Sato M, Matsumoto Y, Morita H, et al. Effects of vitamin supplementation on microcirculatory disturbance in hemodialysis patients without peripheral arterial disease. Clin Nephrol. 2003 Jul;60(1):28-34.

Friedman AN, Bostom AG, Lalibery P, et al. The effect of N-acetylcysteine on plasma total homocysteine levels in hemodialysis: a randomized, controlled study. Am J Kidney Dis. 2003 Feb;41(2):442-6.

Tepel M, van der Giet M, Statz M, et al. The antioxidant, acetylcysteine, reduces cardiovascular events in patients with endstage renal failure: a randomized controlled trial. Circulation. 2003 Feb 25;107(7):992-5.

Ducloux D, Aboubakr A, Motte G, et al. Hyperhomocysteinaemia therapy in haemodialysis patients: folinic versus folic acid in combination with vitamin B6 and B12. Nephrol Dial Transplant. 2002 May;17(5):865-70.

Roes EM, Raijmakers MT, Peters WH, et al. Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women. Clin Chem Lab Med. 2002 May;40(5):496-8.

Teschner M, Kosch M, Schaefer RM. Folate metabolism in renal failure. Nephrol Dial Transplant. 2002;17 Suppl 5:24-7.Erratum in: Nephrol Dial Transplant. 2002 Oct;17(10):1862.

Chevalier CA, Liepa G, Murphy MD, et al. The effects of zinc supplementation on serum zinc and cholesterol concentrations in hemodialysis patients. J Ren Nutr. 2002 Jul;12(3):183-9.

Sunder-Plassmann G, Fodinger M, Buchmayer H, et al. Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna multicenter study. J Am Soc Nephrol. 2000 Jun;11(6):1106-16.

Korzets A, Ori Y, Chagnac A, et al. Erythropoietin, folic acid deficiency and hyperhomocysteinemia: is there a possible relationship in chronically hemodialyzed patients? Clin Nephrol. 2000 Jan;53(1):48-54.

Ventura P, Panini R, Pasini MC, et al. N-Acetylcysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion. Pharmacol Res. 1999 Oct;40(4):345-50.

Makoff R. Vitamin replacement therapy in renal failure patients. Miner Electrolyte Metab. 1999 Jul-Dec;25(4-6):349-51.

Túri S, Németh I, Varga I, et al. Erythropoietin and oxidative stress in haemodialysis: beneficial effects of vitamin E supplementation. Nephrol Dial Transplant. 1999 Jan;14(1):252-3.

Zima T, Tesar V, Mestek O, et al. Trace elements in end-stage renal disease. 2. Clinical implication of trace elements. Blood Purif. 1999;17(4):187-98.

Moustapha A, Naso A, Nahlawi M, et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation. 1998 Jan 20;97(2):138-41. Erratum in: Circulation 1998 Feb 24;97(7):711.

Komindr S, Puchaiwatananon O, Thirawitayakom J, et al. Effects of dietary counseling on vitamin A, B-1, B-2 and zinc status of chronic hemodialysis patients. J Med Assoc Thai. 1997 Nov;80(11):724-30.

Małecka J, Grzeszczak W, Zukowska-Szczechowska EA, et al. [Concentration of chromium in blood serum of patients with chronic renal failure][Article in Polish] Pol Arch Med Wewn. 1995 Jan;93(1):25-31.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.