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Vitamin D3

Vitamin D3
90 capsules

Vitamin D is not only important for proper absorption of calcium and the maintenance of bone health,but also for maintaining healthy joints, a healthy cardiovascular system and healthy moods.*

Quantity

Price: $6.95


Vitamin D3
90 capsules

Vitamin D is not only important for proper absorption of calcium and the maintenance of bone health,
but also for maintaining healthy joints, a healthy cardiovascular system and healthy moods.* In addition,
vitamin D plays an important role in regulating cell division and differentiation and supports immune
system function through its effects on macrophages, natural killer cells (NK) and T cells.* Scientific
data indicate that vitamin D also has a role in helping to maintain breast, prostate, colon and kidney health.*

Vitamin D3 - important for proper absorption of calcium and bone health, maintaining healthy joints, a healthy cardiovascular system and healthy moods.


*These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

Serving Size 1 capsule

Amount Per Serving
Vitamin D3 (as cholecalciferol)............800 IU 200%
Other ingredients: rice flour powder, gelatin, magnesium stearate.

This product contains NO milk, egg, fish, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast,
or gluten.

Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Although manufacturing equipment is thoroughly cleansed after all production runs, this product is manufactured in a facility that utilizes milk, egg, fish, peanuts, crustacean shellfish, soybeans, tree nuts, wheat, yeast, and gluten.

Directions: Take one (1) capsule daily with food, or as directed by your physician.

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis:
results from the Iowa Women's Health Study. Arthritis Rheum. 2004 Jan;50(1):72-7.

McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to
progression of osteoarthritis of the knee among participants in the Framingham study.
Ann Intern Med. 1996 Sep 1;125(5):353-9.

Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of
25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey.
Arch Intern Med. 2007 Jun 11;167(11):1159-65.

Moan J, Porojnicu AC. [The photobiology of vitamin D--a topic of renewed focus] Tidsskr Nor Laegeforen.
2006 Apr 6;126(8):1048-52. Review. Norwegian.

Holick MF. The vitamin D epidemic and its health consequences. J Nutr. 2005 Nov;135(11):2739S-48S.

Levin A, Li YC. Vitamin D and its analogues: do they protect against cardiovascular disease in
patients with kidney disease? Kidney Int. 2005 Nov;68(5):1973-81.

Staud R. Vitamin D: more than just affecting calcium and bone. Curr Rheumatol Rep. 2005 Oct;7(5):356-64.

Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.
Am J Clin Nutr. 2004 Mar;79(3):362-71. Review. Erratum in: Am J Clin Nutr. 2004 May;79(5):890.

Grant WB, Strange RC, Garland CF. Sunshine is good medicine. The health benefits of ultraviolet-B induced
vitamin D production. J Cosmet Dermatol. 2003 Apr;2(2):86-98. Li YC, Kong J, Wei M, et al.
1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.
J Clin Invest. 2002;110(2):229-238. Sigmund CD. Regulation of renin expression and blood pressure by vitamin
D(3). J Clin Invest. 2002;110(2):155-156.
Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D(3) and calcium supplementation on
blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001;86(4):1633-1637.
Sheng H-W. Sodium, chloride and potassium. In: Stipanuk M, ed. Biochemical and Physiological Aspects of
Human Nutrition. Philadelphia: W.B. Saunders Company; 2000:686-710.
Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM. Ultraviolet B and blood pressure.
Lancet. 1998;352(9129):709-710. Scragg R, Khaw KT, Murphy S. Effect of winter oral vitamin D3 supplementation
on cardiovascular risk factors in elderly adults. Eur J Clin Nutr. 1995;49(9):640-646.

Berk M, Sanders KM, Pasco JA, et al. Vitamin D deficiency may play a role in depression. Med Hypotheses. 2007
May 10; [Epub ahead of print]

Gloth FM III, Alam W, Hollis B. Vitamin D vs. broad spectrum phototherapy in the treatment of seasonal effective
disorder. J Nutr Health Aging. 1999;3(1):5-7.

Landsdowne ATG, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology
(Berl). 1998 Feb;135(4):319-23.

Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation.
Annu Rev Nutr. 2003;23:117-145.

Manolagas SC, Provvedini DM, Tsoukas CD. Interactions of 1, 25-dihydroxyvitamin D3 and the immune system.
Mol Cell Endocrinol. 1985 Dec;43(2-3):113-22.

Garland CF, Gorham ED, Mohr SB, et al. Vitamin D and prevention of breast cancer: pooled analysis.
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.

Bertone-Johnson ER, Chen WY, Holick MF, et al. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D
and risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 2005 Aug;14(8):1991-7.

Blutt SE, Weigel NL. Vitamin D and prostate cancer. Proc Soc Exp Biol Med. 1999;221(2):89-98.

John EM, Koo J, Schwartz GG. Sun exposure and prostate cancer risk: evidence for a protective effect of
early-life exposure. Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1283-6.

Grant WB, Garland CF, Gorham ED. An estimate of cancer mortality rate reductions in Europe and the US
with 1,000 IU of oral vitamin D per day. Recent Results Cancer Res. 2007;174:225-34.

Medeiros R, Morais A, Vasconcelos A, et al. The role of vitamin D receptor gene polymorphisms in the
susceptibility to prostate cancer of a southern European population. J Hum Genet. 2002;47(8):413-8.

Ahonen MH, Tenkanen L, Teppo L, et al. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).
Cancer Causes Control 2000;11:847-852.

Garland C, Shekelle RB, Barrett-Connor E, et al. Dietary vitamin D and calcium and risk of colorectal cancer:
a 19-year prospective study in men. Lancet. 1985 Feb 9;1(8424):307-9.

Gorham ED, Garland CF, Garland FC. Et al. Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol.
Biol. 2005 Oct;97(1-2):179-94. Epub 2005 Oct 19.

Hartman TJ, Albert PS, Snyder K, et al. The association of calcium and vitamin D with risk of colorectal adenomas .
J. Nutr. 2005 Feb;135(2):252-9.

Feskanich D, Ma J, Fuchs CS, et al. Plasma vitamin D metabolites and risk of colorectal cancer in women.
Cancer Epidemiol Biomarkers Prev. 2004;13:1501-8

Lieberman DA, Prindiville S, Weiss DG, et al. Risk factors for advanced colonic neoplasia and hyperplastic polyps
in asymptomatic individuals. JAMA. 2003 Dec 10;290(22):2959-67.

Ritter CS, Armbrecht HJ, Slatopolsky E, Brown AJ. 25-Hydroxyvitamin D3 suppresses PTH synthesis and secretion
by bovine parathyroid cells. Kidney Int. 2006 Aug;70(4):654-9. Erratum in: Kidney Int. 2006 Sep;70(6):1190.

Dusso AS, Sato T, Arcidiacono MV, et al. Pathogenic mechanisms for parathyroid hyperplasia.
Kidney Int Suppl. 2006 Jul;(102):S8-11.

Holick MF. Vitamin D for health and in chronic kidney disease. Semin Dial. 2005 Jul-Aug;18(4):266-75.

Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005 Jul;289(1):F8-28.

Vitamin D3
90 capsules

Brown AJ. Therapeutic uses of vitamin D analogues. Am J Kidney Dis. 2001 Nov;38(5 Suppl 5):S3-S19.

MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3.
J Clin Invest 1985;76:1536-1538.

Kessenich CR, Rosen CJ. Vitamin D and bone status in elderly women. Orthop Nurs. 1996 May-Jun;15(3):67-71.

Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D
for multiple health outcomes. Am J Clin Nutr. 2006 Jul;84(1):18-28. Review. Erratum in: Am J Clin Nutr.
2006 Nov;84(5):1253. dosage error in abstract.

Trang HM, Cole DE, Rubin LA, et al. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently
than does vitamin D2. Am J Clin Nutr. 1998 Oct;68(4):854-8.

Grant WB, Garland CF, Holick MF. Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance
and vitamin D and excess solar UV irradiance for the United States. Photochem. Photobiol. 2005 Nov-Dec;81(6):1276-86.

Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to
diagnose, treat, cure, or prevent any disease.


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